Jornada 1
| 04 Jun 22 |  Durazno FC |
1 - 0 |  Salus |
... |
| 04 Jun 22 |  Huracán |
2 - 0 |  Halcones |
... |
| 04 Jun 22 |  Rocha FC |
0 - 3 |  Bella Vista |
... |
| 04 Jun 22 |  Artigas |
4 - 0 |  Parque |
... |
| 04 Jun 22 |  Canadian |
1 - 0 |  Deportivo |
... |
| 04 Jun 22 |  Paysandú |
0 - 1 |  Fondo |
... |
| 05 Jun 22 |  Villa |
4 - 1 |  Salto FC |
... |
| 05 Jun 22 |  Deportivo |
0 - 2 |  Colón FC |
... |
| 05 Jun 22 |  Potencia |
1 - 2 |  Oriental |
... |
| 05 Jun 22 |  Tacuarembó |
2 - 0 |  Platense |
... |
| 05 Jun 22 |  Basáñez |
3 - 0 |  Alto Perú |
... |
Jornada 2
| 12 Jun 22 | Oriental |
2 - 5 | Tacuarembó |
1 |
| 12 Jun 22 | Salus |
0 - 1 | Huracán |
... |
| 12 Jun 22 | Halcones |
2 - 1 | Villa |
... |
| 12 Jun 22 | Fondo |
1 - 0 | Durazno FC |
1 |
| 12 Jun 22 | Bella Vista |
2 - 0 | Paysandú |
... |
| 12 Jun 22 | Colón FC |
3 - 2 | Rocha FC |
... |
| 12 Jun 22 | Salto FC |
1 - 0 | Deportivo |
1 |
| 12 Jun 22 | Parque |
0 - 0 | Potencia |
... |
| 12 Jun 22 | Deportivo |
1 - 0 |  Huracán |
... |
| 12 Jun 22 | Platense |
1 - 3 | Canadian |
... |
| 12 Jun 22 | Alto Perú |
0 - 3 | Artigas |
... |
Jornada 3
| 18 Jun 22 | Deportivo |
3 - 1 | Villa |
... |
| 18 Jun 22 | Bella Vista |
1 - 2 | Durazno FC |
... |
| 19 Jun 22 | Huracán |
0 - 0 | Fondo |
... |
| 19 Jun 22 | Rocha FC |
1 - 2 | Salto FC |
... |
| 18 Jun 22 | Paysandú |
0 - 0 | Colón FC |
... |
| 19 Jun 22 | Salus |
1 - 0 | Halcones |
... |
| 18 Jun 22 | Tacuarembó |
0 - 1 | Potencia |
... |
| 18 Jun 22 | Deportivo |
1 - 0 | Basáñez |
... |
| 19 Jun 22 | Canadian |
0 - 3 | Oriental |
... |
| 19 Jun 22 | Huracán |
0 - 0 | Platense |
... |
| 18 Jun 22 | Alto Perú |
2 - 3 | Parque |
... |
Jornada 4
| 25 Jun 22 | Halcones |
1 - 3 | Deportivo |
... |
| 26 Jun 22 | Villa |
1 - 0 | Rocha FC |
... |
| 26 Jun 22 | Fondo |
0 - 0 | Salus |
... |
| 26 Jun 22 | Bella Vista |
2 - 0 | Huracán |
... |
| 26 Jun 22 | Durazno FC |
0 - 0 | Colón FC |
... |
| 25 Jun 22 | Salto FC |
0 - 1 | Paysandú |
... |
| 25 Jun 22 | Parque |
0 - 5 | Tacuarembó |
... |
| 25 Jun 22 | Potencia |
0 - 1 | Canadian |
... |
| 25 Jun 22 | Deportivo |
1 - 0 | Artigas |
... |
| 26 Jun 22 | Basáñez |
2 - 1 | Platense |
... |
| 26 Jun 22 | Oriental |
1 - 0 | Huracán |
1 |
Jornada 5
| 02 Jul 22 | Fondo |
1 - 0 | Halcones |
... |
| 03 Jul 22 | Durazno FC |
2 - 1 | Salto FC |
... |
| 02 Jul 22 | Huracán |
0 - 0 | Colón FC |
... |
| 02 Jul 22 | Rocha FC |
1 - 1 | Deportivo |
... |
| 02 Jul 22 | Paysandú |
2 - 2 | Villa |
... |
| 02 Jul 22 | Salus |
0 - 1 | Bella Vista |
... |
| 03 Jul 22 | Basáñez |
2 - 3 | Oriental |
... |
| 03 Jul 22 | Artigas |
0 - 3 | Platense |
... |
| 03 Jul 22 | Canadian |
1 - 0 | Tacuarembó |
... |
| 03 Jul 22 | Huracán |
0 - 1 | Potencia |
... |
| 02 Jul 22 | Alto Perú |
0 - 6 | Deportivo |
... |
Jornada 6
| 09 Jul 22 | Halcones |
1 - 8 | Rocha FC |
... |
| 10 Jul 22 | Villa |
1 - 4 | Durazno FC |
... |
| 10 Jul 22 | Deportivo |
2 - 0 | Paysandú |
... |
| 09 Jul 22 | Bella Vista |
1 - 0 | Fondo |
... |
| 10 Jul 22 | Colón FC |
3 - 0 | Salus |
... |
| 09 Jul 22 | Salto FC |
1 - 0 | Huracán |
1 |
| 09 Jul 22 | Parque |
1 - 4 | Canadian |
... |
| 09 Jul 22 | Potencia |
1 - 1 | Basáñez |
... |
| 09 Jul 22 | Tacuarembó |
0 - 1 | Huracán |
... |
| 09 Jul 22 | Platense |
3 - 1 | Alto Perú |
... |
| 09 Jul 22 | Oriental |
1 - 0 | Artigas |
... |
Jornada 7
| 17 Jul 22 | Fondo |
2 - 2 | Colón FC |
... |
| 17 Jul 22 | Durazno FC |
3 - 2 | Deportivo |
... |
| 17 Jul 22 | Bella Vista |
4 - 0 | Halcones |
... |
| 16 Jul 22 | Huracán |
0 - 1 | Villa |
... |
| 16 Jul 22 | Paysandú |
1 - 1 | Rocha FC |
... |
| 17 Jul 22 | Salto FC |
2 - 1 | Salus |
1 |
| 16 Jul 22 | Basáñez |
0 - 1 | Tacuarembó |
... |
| 17 Jul 22 | Deportivo |
2 - 0 | Parque |
... |
| 17 Jul 22 | Artigas |
0 - 2 | Potencia |
... |
| 16 Jul 22 | Huracán |
2 - 3 | Canadian |
... |
| 17 Jul 22 | Oriental |
8 - 0 | Alto Perú |
2 |
Jornada 8
| 24 Jul 22 | Halcones |
2 - 0 | Paysandú |
... |
| 23 Jul 22 | Villa |
1 - 0 | Salus |
... |
| 23 Jul 22 | Deportivo |
3 - 0 | Huracán |
... |
| 24 Jul 22 | Colón FC |
2 - 1 | Bella Vista |
... |
| 23 Jul 22 | Rocha FC |
2 - 0 | Durazno FC |
... |
| 24 Jul 22 | Salto FC |
0 - 1 | Fondo |
... |
| 24 Jul 22 | Parque |
1 - 0 | Huracán |
... |
| 23 Jul 22 | Potencia |
2 - 0 | Alto Perú |
... |
| 23 Jul 22 | Tacuarembó |
2 - 0 | Artigas |
... |
| 23 Jul 22 | Platense |
1 - 0 | Deportivo |
... |
| 23 Jul 22 | Canadian |
2 - 2 | Basáñez |
... |
Jornada 9
| 28 Jul 22 | Fondo |
0 - 1 | Villa |
... |
| 27 Jul 22 | Paysandú |
0 - 2 | Durazno FC |
... |
| 28 Jul 22 | Bella Vista |
1 - 0 | Salto FC |
1 |
| 27 Jul 22 | Colón FC |
2 - 1 | Halcones |
... |
| 26 Jul 22 | Huracán |
0 - 3 | Rocha FC |
... |
| 27 Jul 22 | Salus |
1 - 1 | Deportivo |
... |
| 27 Jul 22 | Huracán |
1 - 2 | Basáñez |
... |
| 27 Jul 22 | Deportivo |
1 - 1 | Oriental |
... |
| 28 Jul 22 | Platense |
1 - 1 | Parque |
... |
| 28 Jul 22 | Artigas |
0 - 0 | Canadian |
... |
| 27 Jul 22 | Alto Perú |
0 - 4 | Tacuarembó |
... |
Jornada 10
| 31 Jul 22 | Villa |
0 - 2 | Bella Vista |
... |
| 31 Jul 22 | Deportivo |
1 - 1 | Fondo |
... |
| 31 Jul 22 | Durazno FC |
1 - 1 | Halcones |
... |
| 31 Jul 22 | Rocha FC |
3 - 1 | Salus |
... |
| 31 Jul 22 | Salto FC |
0 - 1 | Colón FC |
... |
| 30 Jul 22 | Paysandú |
1 - 2 | Huracán |
... |
| 30 Jul 22 | Potencia |
3 - 2 | Deportivo |
... |
| 31 Jul 22 | Basáñez |
3 - 0 | Parque |
... |
| 31 Jul 22 | Canadian |
5 - 1 | Alto Perú |
... |
| 31 Jul 22 | Oriental |
2 - 1 | Platense |
... |
| 31 Jul 22 | Huracán |
2 - 3 | Artigas |
... |
Jornada 11
| 07 Ago 22 | Halcones |
3 - 1 | Salto FC |
... |
| 07 Ago 22 | Fondo |
0 - 0 | Rocha FC |
... |
| 07 Ago 22 | Deportivo |
1 - 3 | Bella Vista |
... |
| 06 Ago 22 | Colón FC |
1 - 1 | Villa |
... |
| 07 Ago 22 | Huracán |
0 - 3 | Durazno FC |
... |
| 06 Ago 22 | Salus |
0 - 2 | Paysandú |
... |
| 07 Ago 22 | Parque |
0 - 1 | Oriental |
... |
| 06 Ago 22 | Tacuarembó |
1 - 1 | Deportivo |
... |
| 06 Ago 22 | Platense |
0 - 3 | Potencia |
... |
| 06 Ago 22 | Artigas |
1 - 0 | Basáñez |
... |
| 06 Ago 22 | Alto Perú |
1 - 1 | Huracán |
... |